Etoposide is an anti-neoplastic agent used in lung and testicular cancers by inhibiting topoisomerase II and causing DNA strand breaks.
Structure of Etoposide
- Etoposide is a podophyllotoxin derivative featuring a dioxolane ring and a dihydropyran ring linked to a benzene ring.
- Chemical Formula: C₂₀H₁₄O₆
Mode of Action
- Topoisomerase II Inhibition: Prevents DNA strand re-ligation, causing DNA breaks.
- DNA Damage: Leads to cell cycle arrest and apoptosis in rapidly dividing cells.
- Apoptosis Induction: Triggers programmed cell death in cancerous cells.
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Uses
- Testicular Cancer: Particularly effective in combination with other agents.
- Lung Cancer: Small cell and non-small cell types.
- Lymphomas: Including Hodgkin’s and non-Hodgkin’s lymphoma.
- Leukemias: Acute myeloid and lymphoblastic leukemia.
- Bone and Soft Tissue Sarcomas: As part of multi-agent chemotherapy regimens.
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