Eutectic mixture - Strategies to Address Eutectic Mixtures

Eutectic Mixture can present challenges during the formulation, compounding, and storage of the final product.
Eutectic Mixture may also impact the drug release profile, bioavailability, and overall therapeutic efficacy of the final product.
When two or more components in a powder formulation form a eutectic mixture, they can create a mass that is sticky, pasty, or even liquid-like at or near the eutectic melting point, which is lower than the melting points of the individual components.
These altered physical properties can cause difficulties in handling, processing, and maintaining the stability of the final powder dosage form.

Physical Separation:
- Microencapsulation can be used to coat one or both components, preventing direct contact and avoiding eutectic formation.
Modification of Components:
- Chemical or physical modifications, such as using different salts, polymorphs, or solvates, can alter melting points and reduce eutectic formation.
Use of Additives:
- Diluents, stabilizers, or anti-caking agents can help prevent eutectic formation by absorbing moisture, reducing interactions, or altering melting points.
Controlled Storage Conditions:
- Temperature and humidity control can help prevent eutectic formation by maintaining storage conditions below the eutectic melting point.