Eye Ointments

Introduction to Eye Ointments:

• Eye ointments are semi-solid preparations intended for sustained drug release
• They are often used for conditions requiring prolonged drug contact, such as dry eye or infections.

Components:

1. Base: Typically, anhydrous and non-irritating (e.g., petrolatum, lanolin).
2. Drug: Antibiotics (e.g., erythromycin), anti-inflammatory agents.
3. Stabilizers and Preservatives: Enhance stability and prevent microbial growth.
4. Surfactants: Improve drug dispersion (e.g., polysorbates).

Method of Preparation:

1. Melting the Base: The ointment base is melted under controlled temperature.
2. Incorporation of Drug: The drug is dispersed or dissolved in the molten base.
3. Sterilization:
   • By heat (e.g., autoclaving the finished ointment).
   • By aseptic incorporation of a sterile drug into a sterilized base.
4. Filling: The sterile ointment is filled into sterilized tubes under aseptic conditions.

Advantages of Eye Ointments:

• Extended Drug Availability: Sustained release of the API.
• Protection of Ocular Surface: Provides a barrier against external irritants.

Examples:

• Antibiotic Ointments: Erythromycin ophthalmic ointment.
• Lubricating Ointment: Petroleum jelly-based eye ointment.

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