Famotidine is a second-generation H₂-receptor antagonist used to treat ulcers, GERD, and acid-related disorders.
Structure of Famotidine
- It is a second-generation H₂-receptor antagonist characterized by a thiazole ring linked to a guanidine moiety and a difluoromethyl group.
- Chemical Formula: C₈H₉N₇O₂S₂
Mode of Action
- Famotidine competitively inhibits H₂ receptors on gastric parietal cells, leading to decreased gastric acid secretion.
- It has a higher affinity for H₂ receptors compared to first-generation antagonists, resulting in prolonged action.
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Uses
- Peptic Ulcers: Facilitates healing by reducing acid secretion.
- GERD: Relieves symptoms by lowering stomach acidity.
- Zollinger-Ellison Syndrome: Controls excessive acid production.
- Prevention of NSAID-Induced Ulcers: Protects against ulcer formation in patients taking nonsteroidal anti-inflammatory drugs.
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