- Felbamate blocks NMDA receptors and modulates GABA, reducing abnormal neuronal excitability.
- It is an anticonvulsant effective in treating partial seizures and Lennox-Gastaut syndrome.
Formula:
- C₁₁H₁₄N₂O₄
Mechanism of Action:
- Blocks NMDA receptors
- Potentiates GABA-A
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Uses of Felbamate:
- Refractory epilepsy
- Lennox-Gastaut syndrome
Side Effects of Felbamate:
- Aplastic anemia
- Hepatotoxicity
- Insomnia, headache
Notes:
Reserved for severe, resistant epilepsy
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