- Filling, Finishing, and Special Techniques of Formulation involve accurately transferring the formulated product into suitable containers, followed by sealing, labeling, and inspection to ensure quality. Specialized techniques enhance stability, efficacy, and product appeal.
- Filling, Finishing, and Special Techniques of Formulation also include advanced processes like lyophilization, aseptic processing, and microencapsulation to improve shelf-life, precision dosing, and targeted delivery in modern pharmaceutical formulations.
Filling:
- Hard gelatin capsules can be filled using various methods depending on the formulation:
- Powders and Granules: Direct filling using tamping or auger mechanisms.
- Pellets: Placed inside the capsule as pre-formed units.
- Liquids and Semi-solids: Requires sealing to prevent leakage.
- Tablet-in-Capsule: Combines a pre-made tablet and powder within the capsule.
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Finishing:
- After filling, capsules are polished to remove dust or adhering particles. Common methods include:
- Brushing: Capsules are rotated against soft brushes.
- Cloth Polishing: Capsules are passed through a polishing pan lined with soft fabric.
Special Techniques of Capsules Formulation:
- Band Sealing: Sealing the capsule with a gelatin band to prevent tampering or leakage.
- Spray Coating: Coating capsules with enteric or controlled-release polymers.
- Liquid-Filled Capsules: Using advanced techniques to fill liquids with appropriate sealing.
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