- Gabapentin modulates calcium channels, reducing excitatory neurotransmitter release in the CNS.
- It is prescribed for neuropathic pain, partial seizures, and restless leg syndrome.
Formula:
- C₉H₁₇NO₂
Mechanism of Gabapentin:
- Binds α2δ subunit of voltage-gated calcium channels
- Reduces excitatory neurotransmitter release
Uses of Gabapentin:
- Partial seizures
- Neuropathic pain
- Postherpetic neuralgia
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Side Effects:
- Drowsiness
- Weight gain
- Ataxia
Notes:
- Not metabolized, excreted unchanged in urine
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