Glipizide is a second-generation sulfonylurea antidiabetic drug used in type 2 diabetes management. It lowers blood sugar by enhancing insulin release from the pancreas and offers greater potency with fewer side effects compared to first-generation agents.
Structure of Glipizide
- Glipizide is a second-generation sulfonylurea with a substituted imidazolidine ring, offering improved potency and shorter half-life.
- Chemical Formula: C₁₅H₂₀ClN₃O₃S
Mode of Action
- ATP-Sensitive K⁺ Channel Blockade: Stimulates insulin release.
- Shorter Half-Life: Reduces risk of prolonged hypoglycemia.
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Uses
- Type 2 Diabetes Mellitus: Effective in controlling postprandial and fasting blood glucose levels.
- Combination Therapy: Often combined with metformin for enhanced glycemic control.
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