Glycine is an inhibitory neurotransmitter in the CNS that regulates motor and sensory pathways.
Function of Glycine:
- Inhibitory neurotransmitter, especially in spinal cord and brainstem.
- Facilitates Cl⁻ influx, similar to GABA-A.
Receptors:
- Glycine receptor (ionotropic Cl⁻ channel)
- Also co-agonist for NMDA glutamate receptor (excitatory role there)
Synthesis Pathway of Glycine:
- Serine → Glycine
- Enzyme: Serine Hydroxymethyltransferase (SHMT)
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Clinical Relevance:
- Involved in motor control.
- Glycine dysfunction implicated in hyperekplexia (startle disease).
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