- Glycopyrrolate reduces secretions, treats peptic ulcers, and aids in anesthesia premedication.
- Glycopyrrolate is an anticholinergic blocking muscarinic receptors with prolonged action.
Chemical Formula:
- C₁₉H₂₈NO₃
Mechanism of Action of Glycopyrrolate:
- M3 antagonist (peripheral) → decreases secretions & GI motility
- Does NOT cross BBB
Therapeutic Uses of Glycopyrrolate:
- Pre-op reduction of saliva and respiratory secretions
- Peptic ulcer treatment
- COPD (as inhaled form: glycopyrronium)
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Side Effects:
- Dry mouth
- Constipation
- Urinary retention
- No CNS side effects due to quaternary nature
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