Guanabenz Acetate is a centrally acting antihypertensive that lowers blood pressure by reducing sympathetic nerve activity.
Structure of Guanabenz Acetate
- It is a guanidine derivative with an aromatic ring substituted with an ethylene bridge connecting to a guanidine moiety.
- Chemical Formula: C₁₀H₁₉N₃O₂S
Mode of Action
- Alpha-2 Adrenergic Agonism: Activates central alpha-2 receptors, reducing sympathetic outflow.
- Sympathetic Inhibition: Lowers blood pressure by decreasing peripheral vascular resistance.
- Enhanced Receptor Sensitivity: Increases the responsiveness of central alpha-2 receptors to endogenous norepinephrine.
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Uses
- Hypertension: Used in the management of essential hypertension.
- Congestive Heart Failure: Reduces afterload and preload, improving cardiac output.
- Rheumatoid Arthritis: Employed off-label for its immunomodulatory effects.
- Preeclampsia: Manages high blood pressure in pregnant women with preeclampsia.
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