Guanethidine Monosulphate is an adrenergic neuron blocker used in hypertension by inhibiting norepinephrine release and lowering blood pressure.
Structure of Guanethidine Monosulphate
- It is a guanidine derivative featuring a guanidine moiety linked to an aromatic ring via an ethylene bridge.
- Chemical Formula: C₁₄H₁₉N₃O₆S
Mode of Action
- Sympathetic Inhibition: Blocks norepinephrine release from postganglionic sympathetic neurons by disrupting storage vesicles.
- Peripheral Effects: Reduces peripheral vascular resistance and cardiac output, lowering blood pressure.
- Renal Effects: Decreases renin secretion, contributing to blood pressure reduction.
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Uses
- Hypertension: Primarily used in severe or resistant hypertension.
- Pheochromocytoma: Manages blood pressure before surgical removal of the tumor.
- Peripheral Vascular Disease: Improves blood flow by reducing vascular resistance.
- Chronic Pain: Sometimes used off-label for its sympatholytic effects.
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