Hydroflumethiazide is a thiazide diuretic used to treat high blood pressure and edema by promoting renal excretion of sodium and water.
Structure of Hydroflumethiazide
- Hydroflumethiazide is a thiazide diuretic with a fluorine atom substitution, enhancing its potency and duration of action.
- Chemical Formula: C₈H₈ClF₅N₃O₄S₂
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Mode of Action
- Thiazide Receptor Blocking: Inhibits the sodium-chloride symporter in the distal convoluted tubule.
- Sodium and Chloride Excretion: Induces diuresis by increasing excretion of sodium and chloride ions.
- Potassium Loss: Promotes excretion of potassium and hydrogen ions, potentially leading to hypokalemia and metabolic alkalosis.
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Uses
- Hypertension: Effective in lowering blood pressure through volume and vascular resistance reduction.
- Edema: Manages fluid retention in conditions like congestive heart failure, liver cirrhosis, and renal disease.
- Nephrolithiasis Prevention: Helps prevent the formation of calcium-based kidney stones.
- Heart Failure: Employed as part of diuretic regimens to control edema.
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