Hydrogen Bonding Definition:
- Hydrogen bonding occurs when hydrogen (H) atoms interact with electronegative atoms (O, N, F). This contributes to a drug’s solubility and receptor binding.
Importance in Drug Action:
- Water Solubility: More hydrogen bonds = better water solubility.
- Receptor Binding: Hydrogen bonds enhance drug-receptor interactions (enzyme active sites, DNA intercalation).
- Stability: Hydrogen bonds stabilize protein structures and drug formulations.
- Permeability: Excessive hydrogen bonding reduces membrane permeability.
Examples of Hydrogen Bonding:
- Antibiotics (e.g., tetracycline): Hydrogen bonding increases solubility and binding to bacterial ribosomes.
- DNA-binding drugs (e.g., cisplatin): Form strong hydrogen bonds with nucleotides.
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