Hyperuricemia

• Hyperuricemia is a condition of elevated uric acid levels in the blood, caused by excess production or reduced excretion.
• Uric acid, the end product of purine metabolism, is primarily excreted by the kidneys, and its buildup can lead to gout and kidney stones.

Causes of Hyperuricemia

1. Increased Uric Acid Production:

   • High purine diet (red meat, seafood).
   • Increased cell turnover (cancers, hemolysis).
   • Genetic disorders (Lesch-Nyhan syndrome).

2. Decreased Uric Acid Excretion:

   • Kidney dysfunction (renal insufficiency).
   • Medications (diuretics, cyclosporine).
   • Metabolic disorders (obesity, insulin resistance).

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