Indomethacin

• Indomethacin is an NSAID used to relieve pain, inflammation, arthritis, and gout.
• It works by inhibiting COX enzymes, reducing prostaglandin synthesis and inflammation.

Chemical Formula:

• C₁₉H₁₆ClNO₄

Mechanism of Action:

• Potent non-selective COX inhibitor
• Reduces inflammation, pain, fever

Uses of Indomethacin:

• Gout (acute)
• RA, OA, ankylosing spondylitis
• Patent ductus arteriosus (PDA) closure in neonates

Side Effects of Indomethacin:

• High GI toxicity
• CNS effects (headache, dizziness, confusion)
• Renal toxicity

SAR Notes:

• Indole ring mimics arachidonic acid
• Acetic acid group critical for COX binding
• Chlorobenzoyl substitution increases potency

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