- Introduction to Autacoids: Local hormones like histamine, serotonin, prostaglandins.
- Introduction to Autacoids: Used in allergy, inflammation, and cardiovascular disorders.
What Are Autacoids?
- Autacoids are biologically active substances produced within the body that act locally to regulate various physiological functions.
- Unlike hormones, which are secreted into the bloodstream and act on distant targets, autacoids exert their effects near their site of synthesis.
- They play crucial roles in modulating processes such as inflammation, vascular tone, and neurotransmission.
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Characteristics of Autacoids and related drug:
- Local Action: They act in the vicinity of their site of production.
- Short-lived Effects: Rapid synthesis and degradation ensure transient effects.
- Receptor Mediated: Their actions are mediated through specific receptors on target cells.
Introduction to Common Classes of Autacoids:
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- Amino Acids: Such as serotonin (5-HT) and substance P.
- Biogenic Amines: Including histamine and catecholamines.
- Eicosanoids: Such as prostaglandins, thromboxanes, and leukotrienes.
- Peptides: Including bradykinin and angiotensin.
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