Isofluorphate (DFP – Diisopropyl fluorophosphate)

• Isofluorphate (DFP – Diisopropyl fluorophosphate) Agents: Potent irreversible cholinesterase inhibitors used in glaucoma.
• Isofluorphate (DFP – Diisopropyl fluorophosphate) Agents: Organophosphate derivative with strong parasympathomimetic action.

Chemical Formula:

• C₃H₈FO₄PS

Mechanism of Action:

• Irreversible AChE inhibitor.
• Covalently binds AChE → long-lasting cholinergic effects.

Uses:

• Previously used for glaucoma (rare today).

Side Effects:

• Cholinergic crisis (if overdosed)
• Muscle twitching, paralysis
• Miosis, bronchoconstriction

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