Lansoprazole, a gastric proton pump inhibitor, effectively reduces stomach acid to treat GERD, ulcers, and acid reflux symptoms.
Structure of Lansoprazole
- It is a benzimidazole derivative similar to Omeprazole, featuring a pyridine ring fused to a benzimidazole core, a sulfoxide group, and an ethoxy group.
- Chemical Formula: C₁₆H₁₈F₂N₃O₂S
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Mode of Action
- Lansoprazole acts as a proton pump inhibitor by irreversibly binding to the H⁺/K⁺-ATPase enzyme in gastric parietal cells, thereby inhibiting gastric acid secretion.
- It forms a covalent disulfide bond with the proton pump, leading to sustained acid suppression.
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Uses
- Peptic Ulcers: Facilitates healing by lowering acid production.
- GERD: Reduces acid reflux and related symptoms.
- Zollinger-Ellison Syndrome: Controls excessive acid secretion.
- Erosive Esophagitis: Promotes healing of esophageal inflammation.
- Helicobacter pylori Eradication: Used in combination with antibiotics for eradication therapy.
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