Levonorgestrel is a synthetic progestin used in birth control and emergency contraception to prevent ovulation and pregnancy.
Structure of Levonorgestrel
- Levonorgestrel is a potent synthetic progestogen, the levorotatory isomer of norgestrel, enhancing its progestational activity.
- Chemical Formula: C₂₀H₂₉NO₂
Mode of Action
- Progestogen Activity: Binds to progesterone receptors, inhibiting ovulation and altering endometrial receptivity.
- Cervical Mucus Thickening: Enhances cervical mucus viscosity, preventing sperm from reaching the ovum.
- Endometrial Alteration: Thins the endometrial lining, reducing the likelihood of implantation.
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Uses
- Oral Contraceptives: Widely used in combined oral contraceptive pills and progestin-only pills.
- Emergency Contraception: Administered as a single-dose pill to prevent pregnancy after unprotected intercourse.
- Menstrual Regulation: Helps in managing heavy menstrual bleeding and irregular cycles.
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