Lisinopril is an ACE inhibitor used to treat hypertension and heart failure by relaxing blood vessels and lowering blood pressure.
Structure of Lisinopril
- It is a long-acting, non-proteinogenic amino acid derivative ACE inhibitor with a lysine moiety.
- Chemical Formula: C₁₉H₃₂N₂O₅
Mode of Action
- ACE Inhibition: Similar to other ACE inhibitors, lisinopril blocks the conversion of angiotensin I to angiotensin II.
- Vasodilation: Results in decreased systemic vascular resistance and blood pressure.
- Renal Protection: Reduces proteinuria and slows progression of kidney disease.
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Uses
- Hypertension: Effective in reducing blood pressure with once-daily dosing.
- Heart Failure: Improves symptoms and reduces mortality when combined with other therapies.
- Post-Myocardial Infarction: Enhances survival and prevents adverse cardiac remodeling.
- Diabetic Nephropathy: Protects renal function in diabetic patients by reducing glomerular pressure.
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