- Loxapine Succinate is an antipsychotic blocking dopamine and serotonin receptors in the CNS.
- It treats schizophrenia by reducing hallucinations, delusions, and agitation.
Chemical Formula:
- C₁₈H₁₈ClN₃O·C₄H₆O₄
Mechanism of Loxapine Succinate:
- Antagonist at D2 and 5-HT2A
- Intermediate between typical and atypical antipsychotics
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Uses of Loxapine Succinate:
- Schizophrenia
- Agitation in bipolar or psychosis (inhalation form)
Side Effects:
- Sedation
- Moderate EPS
- Seizure risk (dose-dependent)
Notes:
- Structurally similar to tricyclic antidepressants
- Rapid-acting inhalation dosage form exists
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