Manufacturing Defects

• Manufacturing Defects in Capsules: Include cracks, deformation, or uneven thickness.
• Manufacturing Defect in Tablets: May involve chipping, capping, or hardness issues.
• Causes: Poor materials, machinery faults, or improper handling.
• Hard gelatin capsules can exhibit defects during production or filling, such as:

1. Cracks: Caused by improper drying or excessive brittleness of gelatin.
2. Deformation: Due to improper storage conditions (e.g., high humidity).
3. Leaks: From improperly sealed liquid-filled capsules.
4. Uneven Thickness: From inconsistent gelatin coating during dipping.
5. Capsule Separation: Caused by poor fitting of cap and body.

Preventions of Manufacturing Defects:

• Optimizing manufacturing parameters (temperature, humidity, viscosity).
• Regular inspection of equipment and raw materials.
• Ensuring proper storage conditions.

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