- Meclofenamate (Meclofenamic acid) is an NSAID effective in pain, inflammation, and arthritis relief.
- It inhibits COX enzymes, reducing prostaglandin synthesis and inflammation.
Chemical Formula:
- C₁₄H₁₁Cl₂NO₂
Mechanism of Action:
- Reversible, non-selective COX-1/COX-2 inhibitor
- Inhibits prostaglandin synthesis
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Uses of Meclofenamate (Meclofenamic acid):
- Mild to moderate pain
- Dysmenorrhea
- Osteoarthritis, rheumatoid arthritis
Side Effects of Meclofenamate (Meclofenamic acid):
- GI irritation
- Headache
- CNS effects (dizziness, drowsiness)
SAR Notes:
- Similar to mefenamic acid, but ortho-dichloro substitution increases potency
- Lipophilic aryl groups = enhanced COX binding
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