Melphalan, an anti-neoplastic alkylating agent, is used to treat multiple myeloma and ovarian cancer by damaging cancer cell DNA and inhibiting growth.
Structure of Melphalan
- Melphalan is an alkylating agent belonging to the nitrogen mustard family, featuring a phenylalanine moiety.
- Chemical Formula: C₁₁H₁₄Cl₂N₂O₂
Mode of Action
- DNA Alkylation: Forms crosslinks with DNA, disrupting DNA synthesis and function.
- Inhibits Cell Division: Prevents cancer cell proliferation by damaging genetic material.
- Induces Apoptosis: Triggers programmed cell death in malignant cells.
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Uses
- Multiple Myeloma: In combination with other chemotherapeutic agents.
- Ovarian Cancer: As part of chemotherapy regimens.
- Breast Cancer: Treatment of metastatic disease.
- Hodgkin’s Lymphoma: In certain treatment protocols.
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