- Metaraminol is a sympathomimetic agent primarily used to treat acute hypotension (low blood pressure), especially during anesthesia or shock.
- It works by stimulating alpha-adrenergic receptors, leading to vasoconstriction (narrowing of blood vessels), which increases blood pressure.
Chemical Structure & Formula
- Chemical Formula: C₉H₁₃NO₂
- Structure:
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Mechanism of Action (Detailed)
- Directly stimulates α1 receptors → Vasoconstriction & increased BP.
- Weak indirect action → Promotes norepinephrine release.
Physiological Effects
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Cardiovascular:
- Increases BP (strong α1 vasoconstriction).
- Minimal effect on HR (little β1 activity).
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Side Effects of Metaraminol
- Hypertension
- Reflex bradycardia
- Tissue necrosis (if extravasation occurs).
Clinical Uses of Metaraminol
- Treatment of hypotension during surgery.
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