- Methacholine is a synthetic choline ester, and a non-selective muscarinic receptor agonist used primarily for diagnostic purposes.
- It mimics the action of acetylcholine on muscarinic receptors, particularly in the lungs and smooth muscles.
Chemical Formula:
- C₈H₁₈ClNO₂
-
Mechanism of Action:
- Selective muscarinic agonist
- Slightly longer acting than ACh due to beta-methyl resistance to AChE.
Uses of Methacholine:
- Diagnosis of bronchial hyperreactivity (asthma test) via inhalation.
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Side Effects of Methacholine:
- Hypotension
- Bradycardia
- Bronchospasm
- Flushing
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