Metharbital

• Metharbital, a barbiturate, enhances GABA activity, producing anticonvulsant and sedative effects.
• It is prescribed for epilepsy, offering control over generalized and partial seizures.

Chemical Formula:

• C₉H₁₄N₂O₃

Mechanism of Action:

• Similar to phenobarbital; enhances GABAergic inhibition

Therapeutic Uses of Metharbital:

• Formerly used for generalized tonic-clonic seizures
• Less potent, more sedating than phenobarbital

Side Effects of Metharbital:

• Drowsiness, ataxia
• Cognitive effects
• Tolerance with long-term use

Notes:

• Now rarely used due to safer alternatives

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