Methazolamide is a carbonic anhydrase inhibitor used to reduce intraocular pressure in glaucoma by decreasing aqueous humor production.
Structure of Methazolamide
- It is a thiazide-like carbonic anhydrase inhibitor with a central sulfonamide group attached to a benzene ring and a thiazole moiety.
- Chemical Formula: C₅H₇N₃O₃S₂
Mode of Action
- Carbonic Anhydrase Inhibition: Similar to acetazolamide, methazolamide inhibits carbonic anhydrase, reducing bicarbonate reabsorption in the kidneys.
- Renal Effects: Increases excretion of bicarbonate, sodium, potassium, and water, leading to diuresis.
- Metabolic Acidosis: Induces a mild metabolic acidosis by lowering blood bicarbonate levels.
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Uses
- Glaucoma: Decreases intraocular pressure by reducing aqueous humor formation.
- Altitude Sickness: Prevents acute mountain sickness through diuretic effects.
- Epilepsy: Used as an adjunctive therapy for seizure control.
- Diuretic: Employed in cases requiring carbonic anhydrase inhibition.
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