Methods to Enhance the Dissolution Rates and Bioavailability of Poorly Soluble Drugs

Methods to enhance the dissolution rates and bioavailability of poorly soluble drugs include particle size reduction and solid dispersions.

Methods to Enhance the Dissolution Rates and Bioavailability of Poorly Soluble Drugs

Many drugs have low solubility, leading to poor bioavailability. Various techniques improve dissolution:

Physicochemical Approaches

1. Particle Size Reduction – Increasing surface area (e.g., micronization, nanosizing).
2. Salt Formation – Converting the drug into a more soluble salt form.
3. Polymorphs and Crystals – Selecting more soluble crystalline forms.
4. Complexation – Using cyclodextrins to form water-soluble complexes.

Formulation Approaches

1. Use of Surfactants – Enhances wetting and solubilization.
2. Solid Dispersions – Drug is dispersed in a hydrophilic carrier (e.g., PEG, PVP).
3. Liposomes and Nanoparticles – Encapsulation for better solubility.
4. Self-Emulsifying Drug Delivery Systems (SEDDS) – Enhances lipid solubility.

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