- Methoxyflurane provides potent inhalation anesthesia and analgesia in medical procedures.
- It is a volatile anesthetic acting on CNS to induce sedation and pain relief.
Chemical Formula:
- C₃H₄Cl₂F₂O
Mechanism of Methoxyflurane:
- Potentiates GABA-A, glycine receptors
- Inhibits neuronal calcium influx
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Uses of Methoxyflurane:
- Historical: inhalational anesthesia
- Current: analgesia in trauma (inhaler) — Australia, New Zealand
Side Effects:
- Nephrotoxicity (fluoride ion accumulation)
- Hypotension
- Respiratory depression
Notes:
- Extremely potent, long duration
- High blood/gas solubility → slow onset and recovery
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