- Metipranolol is a non-selective beta-adrenergic receptor blocker (beta-blocker) used primarily in ophthalmology to reduce intraocular pressure in patients with conditions such as open-angle glaucoma or ocular hypertension.
Chemical Structure & Formula:
- Similar to other beta blockers, featuring an aromatic ring linked to a propanolamine moiety.
- Approximate Formula: C₁₅H₂₂N₂O
Mechanism of Action:
- Acts as a nonselective beta-adrenergic receptor antagonist.
- When administered topically (often in ophthalmic formulations), it reduces aqueous humor production by lowering cAMP in the ciliary epithelium.
Side Effects of Metipranolol:
- Systemically: bradycardia and hypotension
- Topically (ocular): eye irritation, dryness, and transient blurred vision
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Clinical Uses of Metipranolol:
- Primarily indicated for reducing intraocular pressure in glaucoma.
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