Mexiletine Hydrochloride is a class Ib anti-arrhythmic that treats ventricular arrhythmias by stabilizing cardiac conduction.
Structure of Mexiletine Hydrochloride
- Mexiletine hydrochloride is a class IB antiarrhythmic agent, structurally related to lidocaine but with an extended alkyl side chain to enhance oral bioavailability. It exists as the hydrochloride salt.
- Chemical Formula: C₁₆H₂₅N₃O₂ · HCl
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Mode of Action
- Class IB Antiarrhythmic: Blocks fast sodium channels, shortening action potential duration and refractory period.
- Selective on Ventricular Myocytes: More effective in ventricular tissues with rapid action potentials.
- Effect on Heart Rate: Less impact on atrial tissues, making it useful for ventricular arrhythmias without significant atrial suppression.
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Uses
- Ventricular Arrhythmias: Treats ventricular tachycardia and ventricular fibrillation, especially in ischemic heart disease.
- Post-Myocardial Infarction: Prevents arrhythmias in the acute and chronic phases.
- Neuropathic Pain: Used off-label for managing neuropathic pain conditions such as diabetic neuropathy and postherpetic neuralgia.
- Brugada Syndrome: May be used in specific arrhythmic syndromes to stabilize cardiac rhythms.
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