Mifepristone is a progesterone receptor antagonist used for medical abortion and to manage certain hormonal disorders.
Structure of Mifepristone
- Mifepristone is a synthetic steroid with both antiglucocorticoid and antiprogestational properties, featuring a RU486 core structure.
- Chemical Formula: C₂₈H₃₈N₂O₄
Mode of Action
- Progesterone Receptor Antagonism: Blocks progesterone receptors, disrupting the uterine lining and preventing implantation.
- Glucocorticoid Receptor Antagonism: Inhibits cortisol receptors, used in managing hypercortisolism.
- Induction of Labor: Can induce labor by causing uterine contractions.
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Uses
- Medical Abortion: Combined with misoprostol to terminate early pregnancies by preventing implantation and inducing uterine contractions.
- Cushing’s Syndrome: Used to manage endogenous hypercortisolism by blocking cortisol receptors.
- Emergency Contraception: Sometimes used off-label to prevent pregnancy after unprotected intercourse.
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