Mitotane

Structure of Mitotane

• Mitotane is an adrenolytic agent structurally related to the insecticide DDT, featuring a dichlorodiphenyltrichloroethane (DDT) core with modifications.

• Chemical Formula: C₁₈H₁₂Cl₄O

  

  Structure of Mitotane

Mode of Action

• Adrenolytic Effects: Specifically targets and destroys adrenal cortical cells.

• Steroidogenesis Inhibition: Reduces cortisol production by inhibiting enzymes involved in steroid synthesis.

• Apoptosis Induction: Promotes programmed cell death in adrenal cortical carcinoma cells.

Uses

1. Adrenal Cortical Carcinoma: As an adjuvant therapy post-surgery.

2. Cushing's Syndrome: Particularly ectopic or adrenal in origin.

3. Management of Adrenal Insufficiency: By reducing excess hormone production.

4. Breast Cancer: In certain cases where hormone modulation is beneficial.