Mitotane is an anti-neoplastic agent used to treat adrenal cortex cancer by suppressing adrenal function and destroying adrenal cells.
Structure of Mitotane
- Mitotane is an adrenolytic agent structurally related to the insecticide DDT, featuring a dichlorodiphenyltrichloroethane (DDT) core with modifications.
- Chemical Formula: C₁₈H₁₂Cl₄O
Mode of Action
- Adrenolytic Effects: Specifically targets and destroys adrenal cortical cells.
- Steroidogenesis Inhibition: Reduces cortisol production by inhibiting enzymes involved in steroid synthesis.
- Apoptosis Induction: Promotes programmed cell death in adrenal cortical carcinoma cells.
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Uses
- Adrenal Cortical Carcinoma: As an adjuvant therapy post-surgery.
- Cushing’s Syndrome: Particularly ectopic or adrenal in origin.
- Management of Adrenal Insufficiency: By reducing excess hormone production.
- Breast Cancer: In certain cases where hormone modulation is beneficial.
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