Multicompartment Models in Pharmacokinetics explain complex drug distribution and elimination across central and peripheral compartments.
- The body is often not homogeneous; after administration, a drug may distribute at different rates to different tissues.
- Multicompartment models are used to better describe drug distribution and elimination when it doesn’t fit simple one-compartment models.
Definition of Multicompartment Models in Pharmacokinetics:
- These are mathematical models that describe the drug’s movement between multiple compartments (tissue groups with similar blood flow and drug affinity).
- The compartments are theoretical, not anatomical.
Types:
- Two-compartment model (most common):
- Central compartment: blood, liver, kidney – highly perfused tissues.
- Peripheral compartment: muscle, fat – less perfused tissues.
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