- Nalorphine Hydrochloride treats opioid overdose by reversing respiratory depression.
- It acts as a mixed opioid agonist-antagonist at μ and κ receptors.
Chemical Formula:
- C₁₉H₂₁NO₃·HCl
Mechanism of Action:
- Mixed opioid agonist-antagonist
- μ-antagonist → blocks respiratory depression
- κ-agonist → mild analgesia and dysphoria
Advertisements
Therapeutic Uses of Nalorphine Hydrochloride:
- Historically used to reverse opioid overdose
- Replaced by safer agents like naloxone
Side Effects of Nalorphine Hydrochloride:
- Dysphoria, anxiety, hallucinations
- Nausea, vomiting
Notes:
- Prototype opioid antagonist
- Caused too many psychomimetic effects → now obsolete
Thank you for reading from Firsthope's notes, don't forget to check YouTube videos!
