Naphazoline

• Naphazoline is a sympathomimetic agent (a type of drug) that primarily acts as an alpha-adrenergic receptor agonist.
• It is commonly used as a topical decongestant to relieve redness and swelling in the eyes (as in eye drops) or nasal congestion (as in nasal sprays).

Chemical Formula:

• C₁₄H₁4N₂

Basic Structural Features:

• Imidazoline derivative, similar in core structure to oxymetazoline/clonidine but with different ring substitutions.
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Mechanism of Action:

• α1 (and some α2)-adrenergic receptor agonist → vasoconstriction of conjunctival and nasal mucosal blood vessels.

Side Effects of Naphazoline:

• Local irritation, rebound congestion (if used chronically in nasal passages), increased intraocular pressure in predisposed individuals.

Uses of Naphazoline:

• Topical decongestant for red eyes (ophthalmic solution) and nasal congestion (nasal drops).

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