Nateglinide is a meglitinide antidiabetic drug used in the treatment of type 2 diabetes mellitus. It lowers blood sugar by stimulating rapid insulin release from the pancreas, making it particularly effective in controlling post-meal glucose levels. With its fast onset and short duration of action, Nateglinide helps improve glycemic control while reducing the risk of prolonged hypoglycemia.
Structure of Nateglinide
- It is a meglitinide with a pyridine and indole ring system, providing enhanced specificity for pancreatic K⁺
- Chemical Formula: C₁₇H₁₈N₂O
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Mode of Action
- Similar to Repaglinide: Stimulates insulin secretion by blocking K⁺
- Rapid Onset and Short Duration: Effective in managing postprandial hyperglycemia with minimal risk of hypoglycemia.
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Uses
- Type 2 Diabetes Mellitus: Regulates postprandial blood glucose spikes.
- Combination Therapy: Utilized alongside other antidiabetic medications for optimal glycemic management.
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