Nicardipine is a calcium channel blocker used to manage angina and hypertension by easing blood vessel tension and improving flow.
Structure of Nicardipine
- Nicardipine is a dihydropyridine calcium channel blocker with a substituted phenyl ring and a methoxyethyl group attached to the dihydropyridine core.
- Chemical Formula: C₂₂H₂₆N₂O₆
Mode of Action
- Calcium Channel Blocking: Inhibits L-type calcium channels in vascular smooth muscle.
- Vasodilation: Causes significant peripheral arterial dilation, reducing blood pressure.
- Cardiac Effects: May have slight negative inotropic and chronotropic effects at higher doses.
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Uses
- Hypertension: Effective in lowering systemic blood pressure.
- Hypertensive Emergencies: Intravenous formulation used in acute settings.
- Angina Pectoris: Alleviates chest pain by improving myocardial oxygen supply.
- Subarachnoid Hemorrhage: Prevents vasospasm and reduces cerebral vasoconstriction.
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