Nimodipine is a calcium channel blocker used to prevent brain damage after subarachnoid hemorrhage by improving cerebral blood flow.
Structure of Nimodipine
- Nimodipine is a dihydropyridine calcium channel blocker with a substituted phenyl ring and a methoxyethyl side chain attached to the dihydropyridine core.
- Chemical Formula: C₂₄H₃₀N₂O₆
Mode of Action
- Calcium Channel Blocking: Selectively inhibits L-type calcium channels in cerebral vascular smooth muscle.
- Vasodilation: Specifically targets cerebral arteries, preventing vasospasm.
- Neuroprotection: Enhances cerebral blood flow, protecting against ischemic neuronal damage.
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Uses
- Subarachnoid Hemorrhage: Prevents cerebral vasospasm and reduces the risk of delayed ischemic neurological deficits.
- Cerebral Vasospasm: Manages and prevents vasospasm following hemorrhagic stroke.
- Other Cerebrovascular Disorders: May be used off-label for various conditions involving cerebral blood flow impairment.
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