Norgestrel

Norgestrel is a synthetic progestin used in contraceptives to prevent ovulation and regulate menstrual cycles.

Structure of Norgestrel

• Norgestrel is a synthetic progestogen with a 19-nor steroid structure, lacking the carbon at position 19 of the progesterone backbone.
• Chemical Formula: C₂₀H₂₉NO₂

Mode of Action

• Progestogen Activity: Mimics the effects of natural progesterone, regulating the menstrual cycle and preventing ovulation.
• Endometrial Stabilization: Thins the endometrial lining, making it unsuitable for implantation.
• Cervical Mucus Thickening: Increases viscosity of cervical mucus, impeding sperm penetration.

Uses

• Oral Contraception: Used in combination with estrogens in combined oral contraceptive pills to prevent pregnancy.
• Menstrual Disorders: Manages irregular menstrual cycles and reduces menstrual bleeding.
• Endometriosis: Helps in reducing the growth of endometrial tissue outside the uterus.

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