Oestriol is a natural estrogen hormone involved in pregnancy and female reproductive health.
Structure of Oestriol
- Oestriol is one of the three major endogenous estrogens, characterized by a cyclopentanoperhydrophenanthrene structure with three hydroxyl groups.
- Chemical Formula: C₁₈H₂₄O₃
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Mode of Action
- Estrogen Receptor Activation: Binds to estrogen receptors, regulating gene transcription involved in reproductive and non-reproductive functions.
- Bone Density Maintenance: Promotes bone formation and inhibits resorption, reducing osteoporosis risk.
- Cardiovascular Health: Enhances lipid profiles and vasodilation, contributing to cardiovascular protection.
- Skin Health: Promotes collagen synthesis and skin elasticity.
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Uses
- Hormone Replacement Therapy (HRT): Used in postmenopausal women to alleviate menopausal symptoms.
- Pregnancy Support: Supports the maintenance of pregnancy due to its natural increase during gestation.
- Topical Applications: Employed in creams and ointments for skin conditions and anti-aging effects.
- Cancer Therapy: Investigated for roles in hormone-sensitive cancers, though less commonly used compared to other estrogens.
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