Omeprazole is a proton pump inhibitor (PPI) used to treat acid reflux, ulcers, and GERD by blocking gastric acid production.
Structure of Omeprazole
- It is a benzimidazole derivative characterized by a pyridine ring fused to a benzimidazole structure with a sulfoxide group and a methoxy group.
- Chemical Formula: C₁₉H₁₉N₃O₃S
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Mode of Action
- Omeprazole is a proton pump inhibitor (PPI) that irreversibly binds to and inhibits the H⁺/K⁺-ATPase enzyme system (proton pump) in gastric parietal cells.
- This inhibition blocks the final step of gastric acid secretion, leading to a significant and prolonged reduction in stomach acid production.
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Uses
- Peptic Ulcers: Promotes healing by reducing gastric acid secretion.
- Gastroesophageal Reflux Disease (GERD): Alleviates symptoms by decreasing stomach acidity.
- Zollinger-Ellison Syndrome: Manages conditions with excessive acid production.
- Erosive Esophagitis: Heals inflammation and damage to the esophagus.
- Maintenance Therapy: Prevents recurrence of ulcers and GERD symptoms.
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