Paramethadione

• Paramethadione reduces neuronal excitability by blocking T-type calcium channels in the CNS.
• It is prescribed for absence seizures when other treatments are less effective.

Chemical Formula:

• C₆H₁₁NO₂

Mechanism of Action:

• Same as trimethadione (T-type Ca²⁺ channel blocker)

Therapeutic Uses of Paramethadione:

• Absence seizures (less effective than trimethadione)

Side Effects of Paramethadione:

• Milder than trimethadione but still toxic
• GI distress, drowsiness, hypersensitivity

Notes:

• Also withdrawn in most countries
• Used only when other agents fail

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