- Pentazocine is an opioid analgesic for moderate to severe pain relief with lower addiction risk.
- It acts as a kappa agonist and weak mu antagonist, producing analgesia with fewer side effects.
Chemical Formula:
- C₁₉H₂₇NO
Mechanism of Action:
- Kappa agonist + weak μ antagonist
- Produces analgesia with limited euphoria
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Uses of Pentazocine:
- Moderate to severe pain
- May reduce opioid abuse when combined with naloxone
Side Effects of Pentazocine:
- Psychotomimetic effects (hallucinations, nightmares)
- ↑ HR, ↑ BP
- Withdrawal in opioid-dependent individuals
Notes:
- First mixed agonist-antagonist opioid
- Limited use due to CNS side effects
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