- Phenylbutazone blocks COX enzymes, reducing prostaglandin synthesis to relieve pain and swelling.
- It is an NSAID used for arthritis, gout, and pain relief in inflammatory conditions.
Chemical Formula:
- C₁₉H₂₀N₂O₂
Mechanism of Phenylbutazone:
- Potent non-selective COX inhibitor
- Strong anti-inflammatory effect
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Uses of Phenylbutazone:
- Ankylosing spondylitis (rare)
- Gout (historical)
Side Effects:
- Aplastic anemia
- Agranulocytosis
- GI toxicity
Notes:
- Withdrawn or restricted in many countries
- Still used in veterinary medicine.
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