Definition of Physical incompatibilities:
- Physical Incompatibilities involve changes in the appearance, texture, or stability of pharmaceutical formulations when substances with different physical properties are mixed.
- These incompatibilities can affect product quality, efficacy, and safety.
Examples of Physical Incompatibilitie:
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Immiscibility
- Occurs when two liquids do not mix to form a homogeneous solution, leading to phase separation.
- Example: Mixing castor oil with water results in two immiscible layers.
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Insolubility
- Refers to a substance’s inability to dissolve in a particular solvent, causing particle formation or sedimentation.
- Example: Barium sulfate does not dissolve in water, forming an insoluble suspension.
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Precipitation
- The formation of solid particles from a solution, usually due to a chemical reaction or exceeding solubility limits.
- Example: Mixing silver nitrate with sodium chloride results in the precipitation of silver chloride.
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Liquefaction
- Occurs when a solid substance becomes liquid due to temperature changes or interactions with other substances.
- Example: Camphor and menthol form a eutectic mixture, causing liquefaction.
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