Pioglitazone is a thiazolidinedione antidiabetic drug that improves insulin sensitivity and controls blood sugar in type 2 diabetes.
Structure of Pioglitazone
- Pioglitazone is a TZD with a thiazolidinedione ring substituted with a pyridine moiety, enhancing its binding affinity to PPAR-γ.
- Chemical Formula: C₁₄H₁₈N₂O₂S
Mode of Action
- PPAR-γ Agonism: Enhances insulin sensitivity by modulating gene expression related to glucose and lipid metabolism.
- Adipocyte Differentiation: Promotes the formation of insulin-sensitive adipocytes.
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Uses
- Type 2 Diabetes Mellitus: Improves glycemic control by increasing insulin sensitivity.
- Dyslipidemia: Reduces triglycerides and increases HDL cholesterol levels.
- Non-Alcoholic Steatohepatitis (NASH): Investigated for its role in reducing liver fat and inflammation.
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