Plasma Drug Concentration-Time Profile is a graph that represents the concentration of a drug in plasma over time, used to assess and analyze each ADME phase.
Phases of the Profile:
Absorption Phase Drug enters the bloodstream, increasing plasma concentration until it reaches Cmax (maximum concentration).
Distribution Phase Drug disperses to tissues. Influenced by blood flow, lipophilicity, and protein binding.
Metabolism and Elimination Phase Drug is metabolized (mainly in the liver) and excreted, leading to a decline in plasma concentration.
