- Plasma Drug Concentration-Time Profile is a graph that represents the concentration of a drug in plasma over time, used to assess and analyze each ADME phase.
Phases of the Profile:
- Absorption Phase
Drug enters the bloodstream, increasing plasma concentration until it reaches Cmax (maximum concentration). - Distribution Phase
Drug disperses to tissues. Influenced by blood flow, lipophilicity, and protein binding. - Metabolism and Elimination Phase
Drug is metabolized (mainly in the liver) and excreted, leading to a decline in plasma concentration.
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